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Cryo-EM Reveals Crucial Electrical Switch in Brain

Scientists using cryo-EM have revealed the structure of a critical receptor (AMPA) in the brain associated with learning, memory, behavior and mood. The research was also the first to reveal the structure of AMPA receptors in a natural state, a discovery that could lead to new insight about the mechanism...

Researchers Discover Water that Never Freezes

Can water reach -263°C without turning into ice? The answer is yes, according to a group of physicists and chemists from ETH Zurich and the University of Zurich who identified an unusual way to not only prevent water from forming ice crystals while at extreme sub-zero temperatures but to also...

Turning Patient Cells into Cancer Fighters

Cancer therapy could soon include a personalized cancer treatment based on engineered immune cells derived from a patient's individual cells. The approach involves attaching proteins to these cells, receptors that target antigens present in cancer cells to then enable a patient’s immune system to seek out and destroy tumors.

Cold Atoms Act as Distant Messengers

Particles can interact directly by repelling or attracting each other, but how do particles interact when far apart? Scientists at the University of Chicago have discovered that atoms can actually exchange information using intermediary particles. Such research represents the first time this particular phenomenon has been observed in a cold...

Cryo-EM Helps Decipher 3D Structure for Cancer Treatment

A research team from Columbia University and Nimbus Therapeutics has successfully determined the 3D structure of human ATP-citrate lyase (ACLY), a metabolic enzyme that plays a key role in cancer cell proliferation and other cellular processes.

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Joule-Thomson Effect

The Joule-Thomson (JT) effect is a thermodynamic process that occurs when a fluid expands from high pressure to low pressure at constant enthalpy (an isenthalpic process). Such a process can be approximated in the real world by expanding a fluid from high pressure to low pressure across a valve. Under...

Current Leads

One of the challenges of using superconducting magnets is the connection of the magnet to a room temperature power supply. This is accomplished via current leads. The trick is that current leads should ideally have a low heat leak, since they connect room temperature to cryogenic temperature, while at the...

Multilayer Insulation

Multilayer insulation (also referred to as superinsulation) is a key component in the reduction of heat leak to cryogenic systems due to thermal radiation. MLI consists of a series of uncooled reflective surfaces placed in the vacuum space between two surfaces, one warmer than the other. Generally speaking, for ideal...

Cryogenic Treatment of Materials

F.J. Diekman Controlled Thermal Processing, Inc. info@metal-wear.com Cryogenic Processing (also called cryogenic treatment, and incorrectly “cryogenic tempering”) is a process that uses cryogenic temperatures to modify materials to enhance their performance. Cryogenic Processing involves the slow reduction in temperature of the material to at least -300°F (-185°C) and holding the...

Cryogenics in Space

Peter Kittel University of California-Berkeley pkittel@cal.berkeley.edu Space Cryogenics is the application of cryogenics to space missions. These applications fall into two broad areas, supporting space science missions and supporting the space transportation infrastructure. Science applications: The atmosphere is opaque to much of the electro-magnetic spectrum. In space, the absence of...

Cryosurgery

Review of Cryosurgery Boris Rubinsky, PhD Hebrew University School of Science and Engineering Research Center for Biomedical Engineering 78b Ross Building Givat Ram, Jerusalem 91904 Israel rubinsky@cs.huji.ac.il as published in Annual Review of Biomedical Engineering, August 2000, Vol. 2, pp. 157-187. Abstract: Cryosurgery is a surgical technique that employs freezing...

Liquefied Natural Gas

Liquefied Natural Gas as it relates to the Field of Cryogenics John W. Bonn VJ Systems, LLC johnbonn@vjsystems-lic.com Today the world is looking for a cleaner fuel and Liquefied Natural Gas (LNG) plays a large part in achieving this goal. LNG in a liquid form is at -162°C (-259°F) and...

An Issue of Pressure and Flow Rate in a Supply Tank

Please help solve this problem: A supply tank requires a vaporizer to generate sufficient pressure to pump stored fluid up into a vehicle or tank. The available head is limited as the tank level falls and it is important to minimize the system pressure drop to maintain the desired flow...

Using MLI on VJ Line Joints or Cryo Storage Tanks

When installing Multi Layer Insulation (MLI) blankets on VJ line joints or cryo storage tanks should they be wrapped and tied down tight or loose? These are usually pre-cut to size. Also should they have an access hole at the point of where the molecular sieve is installed to help...