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Cryo-EM Reveals Crucial Electrical Switch in Brain

Scientists using cryo-EM have revealed the structure of a critical receptor (AMPA) in the brain associated with learning, memory, behavior and mood. The research was also the first to reveal the structure of AMPA receptors in a natural state, a discovery that could lead to new insight about the mechanism...

Researchers Discover Water that Never Freezes

Can water reach -263°C without turning into ice? The answer is yes, according to a group of physicists and chemists from ETH Zurich and the University of Zurich who identified an unusual way to not only prevent water from forming ice crystals while at extreme sub-zero temperatures but to also...

Working Together as a “virtual telescope,” Observatories Around the World Produce First Direct Images of a Black Hole

MIT News reported on April 10 that an international team of over 200 astronomers had captured the first direct images of a black hole. They accomplished this remarkable feat by coordinating the power of nine major radio observatories on four continents, to work together as a virtual, Earth-sized telescope. In...

Turning Patient Cells into Cancer Fighters

Cancer therapy could soon include a personalized cancer treatment based on engineered immune cells derived from a patient's individual cells. The approach involves attaching proteins to these cells, receptors that target antigens present in cancer cells to then enable a patient’s immune system to seek out and destroy tumors.

Cold Atoms Act as Distant Messengers

Particles can interact directly by repelling or attracting each other, but how do particles interact when far apart? Scientists at the University of Chicago have discovered that atoms can actually exchange information using intermediary particles. Such research represents the first time this particular phenomenon has been observed in a cold...

Cryo-EM Helps Decipher 3D Structure for Cancer Treatment

A research team from Columbia University and Nimbus Therapeutics has successfully determined the 3D structure of human ATP-citrate lyase (ACLY), a metabolic enzyme that plays a key role in cancer cell proliferation and other cellular processes.

Latest in Defining Cryogenics

Regenerators

Regenerators or regenerative heat exchangers are a key component of cryocoolers such as pulse tube cryocoolers (Cold Facts, August 2014). Regenerator performance greatly affects the coefficient of performance of cryocoolers. Improvements in regenerator design and, in particular, regenerator materials have been an important factor in the improvement of the performance...

Pulse Tube Cryocoolers

The development of pulse tube cryocoolers has been a significant topic of research and development over the past 20 or so years. Pulse tube cryocoolers have a number of advantages over other types of cryocoolers and are now available commercially. In order to understand pulse tube cryocoolers, it’s best to...

Thermal Expansion

Thermal expansion refers to the change in size (length or volume) that a material undergoes as its temperature changes. In cryogenic systems this effect can be quite large and must be allowed for in the design. In isotropic materials, which include most engineering materials, the thermal expansion is the same...

Latest in Cryo Central

Cryogenic Treatment of Materials

F.J. Diekman Controlled Thermal Processing, Inc. info@metal-wear.com Cryogenic Processing (also called cryogenic treatment, and incorrectly “cryogenic tempering”) is a process that uses cryogenic temperatures to modify materials to enhance their performance. Cryogenic Processing involves the slow reduction in temperature of the material to at least -300°F (-185°C) and holding the...

Cryogenics in Space

Peter Kittel University of California-Berkeley pkittel@cal.berkeley.edu Space Cryogenics is the application of cryogenics to space missions. These applications fall into two broad areas, supporting space science missions and supporting the space transportation infrastructure. Science applications: The atmosphere is opaque to much of the electro-magnetic spectrum. In space, the absence of...

Cryosurgery

Review of Cryosurgery Boris Rubinsky, PhD Hebrew University School of Science and Engineering Research Center for Biomedical Engineering 78b Ross Building Givat Ram, Jerusalem 91904 Israel rubinsky@cs.huji.ac.il as published in Annual Review of Biomedical Engineering, August 2000, Vol. 2, pp. 157-187. Abstract: Cryosurgery is a surgical technique that employs freezing...

Liquefied Natural Gas

Liquefied Natural Gas as it relates to the Field of Cryogenics John W. Bonn VJ Systems, LLC johnbonn@vjsystems-lic.com Today the world is looking for a cleaner fuel and Liquefied Natural Gas (LNG) plays a large part in achieving this goal. LNG in a liquid form is at -162°C (-259°F) and...

Latest in Ask the Experts

An Issue of Pressure and Flow Rate in a Supply Tank

Please help solve this problem: A supply tank requires a vaporizer to generate sufficient pressure to pump stored fluid up into a vehicle or tank. The available head is limited as the tank level falls and it is important to minimize the system pressure drop to maintain the desired flow...

Using MLI on VJ Line Joints or Cryo Storage Tanks

When installing Multi Layer Insulation (MLI) blankets on VJ line joints or cryo storage tanks should they be wrapped and tied down tight or loose? These are usually pre-cut to size. Also should they have an access hole at the point of where the molecular sieve is installed to help...

Separated layers of ice over a pipe

I want to know that why there are different layers of ice over a pipe carrying a cryogenic fluid, each layer separated with clear marks / lines? What do these layers signify?

Using nitrogen as a cryogen

Is it possible to achieve -200˚C using nitrogen as a cryogen?

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