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Cryo-EM Reveals Crucial Electrical Switch in Brain

Scientists using cryo-EM have revealed the structure of a critical receptor (AMPA) in the brain associated with learning, memory, behavior and mood. The research was also the first to reveal the structure of AMPA receptors in a natural state, a discovery that could lead to new insight about the mechanism...

Researchers Discover Water that Never Freezes

Can water reach -263°C without turning into ice? The answer is yes, according to a group of physicists and chemists from ETH Zurich and the University of Zurich who identified an unusual way to not only prevent water from forming ice crystals while at extreme sub-zero temperatures but to also...

Turning Patient Cells into Cancer Fighters

Cancer therapy could soon include a personalized cancer treatment based on engineered immune cells derived from a patient's individual cells. The approach involves attaching proteins to these cells, receptors that target antigens present in cancer cells to then enable a patient’s immune system to seek out and destroy tumors.

Cold Atoms Act as Distant Messengers

Particles can interact directly by repelling or attracting each other, but how do particles interact when far apart? Scientists at the University of Chicago have discovered that atoms can actually exchange information using intermediary particles. Such research represents the first time this particular phenomenon has been observed in a cold...

Cryo-EM Helps Decipher 3D Structure for Cancer Treatment

A research team from Columbia University and Nimbus Therapeutics has successfully determined the 3D structure of human ATP-citrate lyase (ACLY), a metabolic enzyme that plays a key role in cancer cell proliferation and other cellular processes.

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Dewar

A dewar is a type of cryostat named after Sir James Dewar, the researcher who first developed the concept of a vacuum insulated container with silvered walls to reflect thermal radiation. Dewar was the first to liquefy hydrogen, and he created the device to store his discovery. The thermos bottle...

Stirling and Gifford-McMahon Cryocoolers

Stirling and Gifford-McMahon (GM) cryocoolers are two of the most commonly used cryocoolers in cryogenics. Both devices have a significant industrial base and operate at a wide range of temperatures and capacities. The thermodynamic cycles for both of these cryocoolers are quite similar. The Stirling cycle consists of a compressor,...

Liquefied Natural Gas (LNG)

A significant commercial application of cryogenics is the liquefaction, transport and storage of natural gas. Liquefied Natural Gas (LNG) is generally 95 percent methane with a few percent ethane and much lower concentrations of propane and butane. LNG liquefies at 111.6 K. Unlike many applications of cryogenics, the motivation for...

Magnets

From “Superconductivity: Present and Future Applications” by the Coalition for the Commercial Application of Superconductors. Particle physics uses accelerators to recreate the conditions of the early universe in an attempt to piece together the complex puzzle of how we got to where we are today. These huge machines are used...

Energy Storage

From “Superconductivity: Present and Future Applications” by the Coalition for the Commercial Application of Superconductors. With power lines increasingly congested and prone to instability, strategic injection of brief bursts of real power can play a crucial role in maintaining grid reliability. Small-scale Superconducting Magnetic Energy Storage (SMES) systems, based on...

Astronomy

ASTRONOMY IN SPACE by Peter V. Mason, retired,  Jet Propulsion Laboratory, and Visiting Associate, California Institute of Technology. Pmason@alumni.caltech.edu In thinking about the reasons to perform astronomy in space, we first consider the effect of the earth’s atmosphere.  On a scale of decreasing energy, gamma rays, cosmic rays, X-rays and...

Cryocoolers

What is a Cryocooler? A mechanism that can extract heat from an object (cooler) and by doing so draw its temperature down below approximately 150 Kelvin (cryo). — (Courtesy Dr. Willy Gully) What is the difference between a Cryocooler and a Cryostat? A cryostat is any device designed to maintain...

Assistance with resolving a sealing problem?

We are fabricating piping components for refrigeration service. These components must be leak checked at 15 bar (218 psig). We are using a gas test media that is 25% helium and experiencing difficulty on maintaining a seal on the flanged connections. Do you know anyone or any references that could...

Cryogenic data on leather and nomex

Could anyone please help me out with the following cryogenics data: Leather — mechanical properties at 77 K or lower Nomex — thermal conductivity @ 4 to 50 K I lost the data I had some time ago and although this should be easily accessible, I can’t find any reference...