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Cryo-EM Reveals Crucial Electrical Switch in Brain

Scientists using cryo-EM have revealed the structure of a critical receptor (AMPA) in the brain associated with learning, memory, behavior and mood. The research was also the first to reveal the structure of AMPA receptors in a natural state, a discovery that could lead to new insight about the mechanism...

Researchers Discover Water that Never Freezes

Can water reach -263°C without turning into ice? The answer is yes, according to a group of physicists and chemists from ETH Zurich and the University of Zurich who identified an unusual way to not only prevent water from forming ice crystals while at extreme sub-zero temperatures but to also...

Turning Patient Cells into Cancer Fighters

Cancer therapy could soon include a personalized cancer treatment based on engineered immune cells derived from a patient's individual cells. The approach involves attaching proteins to these cells, receptors that target antigens present in cancer cells to then enable a patient’s immune system to seek out and destroy tumors.

Cold Atoms Act as Distant Messengers

Particles can interact directly by repelling or attracting each other, but how do particles interact when far apart? Scientists at the University of Chicago have discovered that atoms can actually exchange information using intermediary particles. Such research represents the first time this particular phenomenon has been observed in a cold...

Cryo-EM Helps Decipher 3D Structure for Cancer Treatment

A research team from Columbia University and Nimbus Therapeutics has successfully determined the 3D structure of human ATP-citrate lyase (ACLY), a metabolic enzyme that plays a key role in cancer cell proliferation and other cellular processes.

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Two-Phase Flows

Two-phase flows are those flows in which there is a mixture of two physical states (solid, liquid or vapor). In cryogenic applications, such flows are almost always a mixture of a cryogenic liquid along with its corresponding vapor. A mixture of liquid helium and helium vapor would be a typical...

Supercritical Fluids

A supercritical fluid is defined as a substance whose temperature and pressure exceed those of its critical point. Every pure substance has a critical point that is defined in thermodynamic space by a critical temperature and a corresponding critical pressure. For example, the critical point for helium has a critical...

Brayton Cycle

The Brayton cycle is one of the many thermodynamic cycles used to generate cooling at cryogenic temperatures. Strictly speaking, when referring to cooling we should call this the reverse Brayton cycle as the original Brayton cycle describes the process of power generation or propulsion via a gas turbine. In many...

Magnets

From “Superconductivity: Present and Future Applications” by the Coalition for the Commercial Application of Superconductors. Particle physics uses accelerators to recreate the conditions of the early universe in an attempt to piece together the complex puzzle of how we got to where we are today. These huge machines are used...

Energy Storage

From “Superconductivity: Present and Future Applications” by the Coalition for the Commercial Application of Superconductors. With power lines increasingly congested and prone to instability, strategic injection of brief bursts of real power can play a crucial role in maintaining grid reliability. Small-scale Superconducting Magnetic Energy Storage (SMES) systems, based on...

Astronomy

ASTRONOMY IN SPACE by Peter V. Mason, retired,  Jet Propulsion Laboratory, and Visiting Associate, California Institute of Technology. Pmason@alumni.caltech.edu In thinking about the reasons to perform astronomy in space, we first consider the effect of the earth’s atmosphere.  On a scale of decreasing energy, gamma rays, cosmic rays, X-rays and...

Cryocoolers

What is a Cryocooler? A mechanism that can extract heat from an object (cooler) and by doing so draw its temperature down below approximately 150 Kelvin (cryo). — (Courtesy Dr. Willy Gully) What is the difference between a Cryocooler and a Cryostat? A cryostat is any device designed to maintain...

An Issue of Pressure and Flow Rate in a Supply Tank

Please help solve this problem: A supply tank requires a vaporizer to generate sufficient pressure to pump stored fluid up into a vehicle or tank. The available head is limited as the tank level falls and it is important to minimize the system pressure drop to maintain the desired flow...

Using MLI on VJ Line Joints or Cryo Storage Tanks

When installing Multi Layer Insulation (MLI) blankets on VJ line joints or cryo storage tanks should they be wrapped and tied down tight or loose? These are usually pre-cut to size. Also should they have an access hole at the point of where the molecular sieve is installed to help...