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Electron Camera at SLAC Films High-speed Molecular Movie

Researchers using an extremely fast electron camera at the Department of Energy’s SLAC National Accelerator Laboratory have made the first high-definition “movie” of ring-shaped molecules breaking open in response to light.

Cryo-EM Reveals Crucial Electrical Switch in Brain

Scientists using cryo-EM have revealed the structure of a critical receptor (AMPA) in the brain associated with learning, memory, behavior and mood. The research was also the first to reveal the structure of AMPA receptors in a natural state, a discovery that could lead to new insight about the mechanism...

Researchers Discover Water that Never Freezes

Can water reach -263°C without turning into ice? The answer is yes, according to a group of physicists and chemists from ETH Zurich and the University of Zurich who identified an unusual way to not only prevent water from forming ice crystals while at extreme sub-zero temperatures but to also...

Turning Patient Cells into Cancer Fighters

Cancer therapy could soon include a personalized cancer treatment based on engineered immune cells derived from a patient's individual cells. The approach involves attaching proteins to these cells, receptors that target antigens present in cancer cells to then enable a patient’s immune system to seek out and destroy tumors.

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Dilution Refrigerators

Dilution refrigerators are a common technique for reaching temperatures below 1K, particularly where continuous cooling at these temperatures is required. Helium exists in two stable isotopes: 4He and 3He. Naturally occurring 3He is extremely rare, constituting less than 1 part per million of helium gas. However, 3He can be manufactured,...

Oxygen Deficiency Hazards

Oxygen Deficiency Hazards (ODH) are a significant safety issue in cryogenic facilities. ODH occurs when inert gases such as nitrogen, helium or argon displace room air and thus lower the percentage of oxygen in the space below that required for human life. OSHA defines an area as oxygen deficient if...

Kelvin Temperature Scale

The Kelvin temperature scale is the principal temperature scale used in cryogenics and science. The kelvin is also one of the seven base units in the Système International d’Unités (SI) and is the unit of thermodynamic temperature. Thermodynamic temperature is a fundamental physical quantity (like mass, length or electrical current)...

History of Cryogenics

From the Fall 1999 issue of Cold Facts magazine Millennium Breakthroughs A variety of CSA members give different perspectives on the past millennium: What were the most significant breakthroughs in cryogenics during the past millennium? Prof. R.G. Scurlock, Kryos Technology, scurlock@soton.ac.uk (“Breakthrough” = way through obstacles — Oxford English Dictionary)...

Cryobiology

Andreas Sputtek Past President Society for Cryobiology sputtek@uke.uni-hamburg.de or http://www.sputtek.de/. The word cryobiology (from the Greek words “cryo” = cold, “bios” = life, and “logos” = science) literally signifies the science of life at low temperatures. In practice, this field comprises the study of any biological material or system (e.g.,...

Cryogenic Insulation

James E. Fesmire Cryogenics Test Laboratory NASA Kennedy Space Center james.e.fesmire@nasa.gov Introduction In today’s world, the use of cryogenics and low-temperature refrigeration is taking a more and more significant role. From the food industry, transportation, energy, and medical applications to the Space Shuttle, cryogenic liquids must be stored, handled, and...

Cryogenic Treatment of Materials

F.J. Diekman Controlled Thermal Processing, Inc. info@metal-wear.com Cryogenic Processing (also called cryogenic treatment, and incorrectly “cryogenic tempering”) is a process that uses cryogenic temperatures to modify materials to enhance their performance. Cryogenic Processing involves the slow reduction in temperature of the material to at least -300°F (-185°C) and holding the...

An Issue of Pressure and Flow Rate in a Supply Tank

Please help solve this problem: A supply tank requires a vaporizer to generate sufficient pressure to pump stored fluid up into a vehicle or tank. The available head is limited as the tank level falls and it is important to minimize the system pressure drop to maintain the desired flow...

Using MLI on VJ Line Joints or Cryo Storage Tanks

When installing Multi Layer Insulation (MLI) blankets on VJ line joints or cryo storage tanks should they be wrapped and tied down tight or loose? These are usually pre-cut to size. Also should they have an access hole at the point of where the molecular sieve is installed to help...