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New Microscope Advances Cryo-ET Research

Thermo Fisher Scientific Inc. unveiled the Thermo Scientific Arctis Cryo-Plasma Focused Ion Beam (Cryo-PFIB), a new connected and automated microscope designed to advance the pace of cryo-electron tomography (cryo-ET) research. Cryo-ET makes it possible to study how proteins and other molecules operate together in a cellular context, at resolutions unsurpassed by...

Excavation of Huge Caverns for DUNE Particle Detector Underway

Around a mile below the surface in South Dakota, construction crews are hard at work excavating around 1,000 tons of rock per day. Their goal is to make room for a large underground facility that will house an international effort aimed at studying neutrinos—highly elusive subatomic particles that may hold...

In DNA–Scientists find solution to building superconductor that could transform technology

Scientists at the University of Virginia School of Medicine and their collaborators have used DNA to overcome a nearly insurmountable obstacle to engineer materials that would revolutionize electronics.  One possible outcome of such engineered materials could be superconductors, which have zero electrical resistance, allowing electrons to flow unimpeded. That means...

Researchers Take First-Ever Cryo-EM Images of Nitrogenase in Action

Previously, it has been impossible to capture the high-resolution images of nitrogenase, the only enzyme capable of reducing nitrogen into ammonia, during catalytic action. Now, for the first time, researchers at the University of California San Diego report near-atomic-resolution snapshots of nitrogenase during catalysis using cryogenic electron microscopy (cryoEM). The...

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Mixed Refrigerant Cycles

Most cryogenic refrigeration systems, both large scale systems and cryocoolers, use helium as a working fluid. There are a number of advantages to helium, not the least of which is that helium remains a fluid down to the lowest achievable temperatures. In order to freeze helium, pressures of over 20...

Fountain Pumps and He II Phase Separators

Helium II (He II), the second liquid phase of the 4He isotope described in this column in Cold Facts Spring 2010 (http://2csa.us/he2), can be modeled as consisting of two interpenetrating fluids. One, the superfluid component, has zero viscosity and entropy and the other, the normal fluid component, has nonzero viscosity...

Turboexpanders

A vital technology in the refrigerators and liquefiers described in Cold Facts Volume 31 Number 3 is that of turboexpanders. These devices are rotating machines in which the process fluid (e.g., helium) does work against the turboexpander while moving from high pressure to a lower pressure and thus is cooled....

Air Separation and Liquefaction

by Nils Tellier, PE, President, EPSIM Corporation (CSA CSM) nils@epsim.us All illustrations courtesy EPSIM Corporation Background History of Air Separation and Liquefaction This section builds on a rich history of methods to develop deep refrigeration and cryogenic liquefaction during the 19th Century. You are encouraged to read Cryo Central’s History...

Bose-Einstein Condensate

A Bose-Einstein condensate, first proposed in 1925 by Albert Einstein based on work done by Satyendra Nath Bose (the same Bose from whom the term boson is derived), is a super-cold state of matter in which almost all of the individual atoms have “condensed” down to the lowest possible quantum...

Cold Technology for Pest Control

While it does not reach temperatures cold enough to be called cryogenic, carbon dioxide snow is at the heart of a new way of dealing with unwanted pests. It utilizes a quick freezing process that takes advantage of the properties of carbon dioxide snow and has a number of benefits...

Cryogenic Finishing

The following 3 articles discuss the uses and procedures of various type of cryogenic finishing. 1) By Robin A. Rhodes, Cryogenic Institute of New England, Inc. rrhodes@nitrofreeze.com Cryogenic Deflashing is employed to remove undesired residual mold flash that remains on molded parts after they are removed or ejected from the...

Suppliers of regenerator materials

I was looking for suppliers of regenerator materials. Can you please provide a list of vendors for: • Lead spheres • Bronze screen discs • Rare earth materials and spheres Thank you in advance for any help you can provide.

Containing ice accumulation while recovering helium

We are implementing a system to recover helium from our Janis ST-500 continuous flow LHe cryostat. The recovery system uses standard 1/4″ plastic tubing, which we connect directly to the cryostat’s exhaust port. The problem with this setup is that the gas is still quite cold as it leaves the...