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Cryo-EM Reveals Crucial Electrical Switch in Brain

Scientists using cryo-EM have revealed the structure of a critical receptor (AMPA) in the brain associated with learning, memory, behavior and mood. The research was also the first to reveal the structure of AMPA receptors in a natural state, a discovery that could lead to new insight about the mechanism...

Researchers Discover Water that Never Freezes

Can water reach -263°C without turning into ice? The answer is yes, according to a group of physicists and chemists from ETH Zurich and the University of Zurich who identified an unusual way to not only prevent water from forming ice crystals while at extreme sub-zero temperatures but to also...

Working Together as a “virtual telescope,” Observatories Around the World Produce First Direct Images of a Black Hole

MIT News reported on April 10 that an international team of over 200 astronomers had captured the first direct images of a black hole. They accomplished this remarkable feat by coordinating the power of nine major radio observatories on four continents, to work together as a virtual, Earth-sized telescope. In...

Turning Patient Cells into Cancer Fighters

Cancer therapy could soon include a personalized cancer treatment based on engineered immune cells derived from a patient's individual cells. The approach involves attaching proteins to these cells, receptors that target antigens present in cancer cells to then enable a patient’s immune system to seek out and destroy tumors.

Cold Atoms Act as Distant Messengers

Particles can interact directly by repelling or attracting each other, but how do particles interact when far apart? Scientists at the University of Chicago have discovered that atoms can actually exchange information using intermediary particles. Such research represents the first time this particular phenomenon has been observed in a cold...

Cryo-EM Helps Decipher 3D Structure for Cancer Treatment

A research team from Columbia University and Nimbus Therapeutics has successfully determined the 3D structure of human ATP-citrate lyase (ACLY), a metabolic enzyme that plays a key role in cancer cell proliferation and other cellular processes.

Latest in Defining Cryogenics

Stability

Stability refers to the ability of a device employing superconductors to remain in its superconducting state after part of the superconductor transitions back to its normal conducting state due to a disturbance. While the concept can apply to many superconducting devices—transmission lines, generators, motors, etc.—it is most commonly considered in...

Cable-in-Conduit Conductors

Cable-in-Conduit Conductors (CICC) are a common form of superconducting cable used in large-scale applications. There are several varieties of CICCs, but they all consist of many small, stabilized superconducting wires contained within a conduit through which a coolant (typically supercritical He II) flows. Figure 1 shows the cross section of...

Bayonet Coupling

A bayonet coupling is a demountable joint that allows for quick and easy connection and disconnection of cryogenic components, including transfer lines, cryostats, liquefiers and refrigerators. Bayonets provide a number of advantages, chief among them the ability to connect and disconnect the bayonets while components they connect are still at...

Latest in Cryo Central

Air Separation and Liquefaction

by Nils Tellier, PE, President, EPSIM Corporation (CSA CSM) nils@epsim.us All illustrations courtesy EPSIM Corporation Background History of Air Separation and Liquefaction This section builds on a rich history of methods to develop deep refrigeration and cryogenic liquefaction during the 19th Century. You are encouraged to read Cryo Central’s History...

Bose-Einstein Condensate

A Bose-Einstein condensate, first proposed in 1925 by Albert Einstein based on work done by Satyendra Nath Bose (the same Bose from whom the term boson is derived), is a super-cold state of matter in which almost all of the individual atoms have “condensed” down to the lowest possible quantum...

Cold Technology for Pest Control

While it does not reach temperatures cold enough to be called cryogenic, carbon dioxide snow is at the heart of a new way of dealing with unwanted pests. It utilizes a quick freezing process that takes advantage of the properties of carbon dioxide snow and has a number of benefits...

Cryogenic Finishing

The following 3 articles discuss the uses and procedures of various type of cryogenic finishing. 1) By Robin A. Rhodes, Cryogenic Institute of New England, Inc. rrhodes@nitrofreeze.com Cryogenic Deflashing is employed to remove undesired residual mold flash that remains on molded parts after they are removed or ejected from the...

Latest in Ask the Experts

Need help comparing chest freezers and upright freezers

Currently we use in our Biobank an upright -80 freezer to store all our samples. We are planning to buy a fully automated bio-repository storage that will do the picking of samples under restricted conditions. But in the meantime I foresee that we have to pick the samples manually. The...

Need recommendations for cryogenic vials

I am looking into standardizing our range of bio storage tubes (cryogenic vials). These will be for both blood and tissue samples and their derivatives. Any recommendations, comments on Micronics, Nalgene, Nunc and or others that are suitable for long term -80 C and -196 C storage, DNA/RNA suitable, would...

We need a custom machine for flash freezing of water

We are an ice making company and have started a new project, which is related to flash freezing of water. It is based on cryogenics technology and we need a custom made machine. I would kindly ask you to pass me a few companies who would be interested in such...

Looking for a pump suitable for cold liquids

I would like to construct a small cooling circuit (appr. 50 x 50 cm) pumping liquid at a temperature down to -120°C from a cold reservoir to the specimen to be cooled. The tubes and connections are not a problem, but does somebody know a pump (suction/compression for circulation) suitable...

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