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High-Resolution Cryo-EM Starts Focusing on Accessibility

Structure-based designs are integral to advancing drug discovery, and in this regard, cryogenic electron microscopy (cryo-EM) has emerged as a pivotal tool for achieving high-resolution structures of proteins and protein complexes. Particularly noteworthy is its utility in elucidating the structures of protein classes that have historically resisted crystallization. Cryo-EM’s pivotal...

Cryogenic Etch Re-Emerges

Cryogenic etch, sometimes called cryo etch, is one of two ways to enable deep silicon or high-aspect ratio (HAR) etches in devices, where the features are long, narrow and deep. The other and most popular method is the two-step Bosch process, where you etch out a part of the structure...

RegO Adds Pressure Regulators for Cryogenic Vessels

RegO Products has unveiled its latest breakthrough: the CBE504 Series of Half-Inch Pressure Builder-Economizer Regulators. Designed to enhance cryogenic vessel operations, these regulators prioritize pressure control and product preservation. The CBE504 Series boasts numerous improvements over the previous CB504 model, including a more compact form factor and a broader range...

Tokamak Energy’s Fusion Magnet System Passes Cryogenic Tests

UK-based Tokamak Energy’s superconducting magnet system, which is being built to replicate fusion energy power plant forces, has passed significant milestone cryogenic tests. Creating fusion energy requires strong magnetic fields to confine and control the extremely hot hydrogen fuel, which becomes a plasma several times hotter than the center of...

Ziath Preserves the Future, One Sample at a Time

In the realm of scientific discovery, the value of biological specimens cannot be overstated. They serve as essential windows into understanding life’s intricate mysteries. From the smallest molecules to the most complex organisms, researchers strive to unlock the secrets held within these samples. To safeguard these invaluable assets, a pioneering...

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Dewar

A dewar is a type of cryostat named after Sir James Dewar, the researcher who first developed the concept of a vacuum insulated container with silvered walls to reflect thermal radiation. Dewar was the first to liquefy hydrogen, and he created the device to store his discovery. The thermos bottle...

Stirling and Gifford-McMahon Cryocoolers

Stirling and Gifford-McMahon (GM) cryocoolers are two of the most commonly used cryocoolers in cryogenics. Both devices have a significant industrial base and operate at a wide range of temperatures and capacities. The thermodynamic cycles for both of these cryocoolers are quite similar. The Stirling cycle consists of a compressor,...

Liquefied Natural Gas (LNG)

A significant commercial application of cryogenics is the liquefaction, transport and storage of natural gas. Liquefied Natural Gas (LNG) is generally 95 percent methane with a few percent ethane and much lower concentrations of propane and butane. LNG liquefies at 111.6 K. Unlike many applications of cryogenics, the motivation for...

Food Processing

Cryogenics and Food The industrial gas industry provides a host of products and services related to food. The various gases have useful and sometimes fascinating applications in food industry. “The food industry is not a homogenous industry. The needs of customers processing hamburger vs. poultry vs. strawberries vs. seafood, for...

Primary Standards

Elie K. Track Hypres, Inc. elie@hypres.com http://www.hypres.com/ Primary standards involve the exact definition and realization of units of measurement for various quantities, time, length, mass, voltage, resistance, current, etc. International agreements based on the latest scientific knowledge define those units, and their realizations vary depending on the unit itself. For...

Shrink Fitting

Robin A. Rhodes Cryogenic Institute of New England, Inc. rrhodes@nitrofreeze.com Shrink fitting, (or “compression fitting” as it is sometimes called), is a method used to insert a pin or bushing into a housing or other assembly requiring an extremely tight tolerance fit. It can be used as an alternative to...

Telecommunications

From the Winter 2004 issue of Cold Facts magazine The recent M-Calc IV — 4th Industry Assessment workshop discussing military and commercial applications for low-cost cryocoolers, held in November in San Diego, highlighted progress being made in cryogenics as applied in telecommunications. The reliability and long lifetime of projects now...

Need help comparing chest freezers and upright freezers

Currently we use in our Biobank an upright -80 freezer to store all our samples. We are planning to buy a fully automated bio-repository storage that will do the picking of samples under restricted conditions. But in the meantime I foresee that we have to pick the samples manually. The...

Need recommendations for cryogenic vials

I am looking into standardizing our range of bio storage tubes (cryogenic vials). These will be for both blood and tissue samples and their derivatives. Any recommendations, comments on Micronics, Nalgene, Nunc and or others that are suitable for long term -80 C and -196 C storage, DNA/RNA suitable, would...

We need a custom machine for flash freezing of water

We are an ice making company and have started a new project, which is related to flash freezing of water. It is based on cryogenics technology and we need a custom made machine. I would kindly ask you to pass me a few companies who would be interested in such...

Looking for a pump suitable for cold liquids

I would like to construct a small cooling circuit (appr. 50 x 50 cm) pumping liquid at a temperature down to -120°C from a cold reservoir to the specimen to be cooled. The tubes and connections are not a problem, but does somebody know a pump (suction/compression for circulation) suitable...